Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells
- 주제(키워드) Alpinia oxyphylla , eudesmane sesquiterpene , eremophilane sesquiterpene , adipose-derived mesenchymal stem cell , antioxidant , oxidative stress
- 주제(기타) Biochemistry & Molecular Biology
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Thapa, Punam; Tiep Tien Nguyen; Choi, Hyukjae; Jeong, Jee-Heon; Nam, Joo-Won] Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbukdo, South Korea; [Lee, Yoo Jin; Piao, Donglan; Lee, Hwaryeong; Han, Sujin; Lee, Yeon Jin; Seo, Eun Kyoung] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Han, Ah-Reum] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup Si 56212, Jeollabuk Do, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181575
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/molecules26061762
초록/요약
Alpinia oxyphylla Miquel (Zingiberaceae) has been reported to show antioxidant, anti-inflammatory, and neuroprotective effects. In this study, two new eudesmane sesquiterpenes, 7 alpha-hydroperoxy eudesma-3,11-diene-2-one (1) and 7 beta-hydroperoxy eudesma-3,11-diene-2-one (2), and a new eremophilane sesquiterpene, 3 alpha-hydroxynootkatone (3), were isolated from the MeOH extract of dried fruits of A. oxyphylla along with eleven known sesquiterpenes (4-14). The structures were elucidated by the analysis of 1D/2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and optical rotation data. Compounds (1-3, 5-14) were evaluated for their protective effects against tert-butyl hydroperoxide (tBHP)-induced oxidative stress in adipose-derived mesenchymal stem cells (ADMSCs). As a result, treatment with isolated compounds, especially compounds 11 and 12, effectively reverted the damage of tBHP on ADMSCs in a dose-dependent manner. In particular, 11 and 12 at 50 mu M improved the viability of tBHP-toxified ADMSCs by 1.69 +/- 0.05-fold and 1.61 +/- 0.03-fold, respectively.
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