Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy
- 주제(키워드) Photodynamic therapy , Redox-responsive , ROS , Self-assembled nanoparticles , Tumour targeting
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181727
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.dyepig.2021.109307
초록/요약
The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT). © 2021 Elsevier Ltd
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