Synthesis of 1 H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C-H Bond Amination
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181765
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acsomega.1c00025
초록/요약
We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant. © 2021 The Authors. Published by American Chemical Society.
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