Poly(Ethylene glycol)-poly(l-alanine)/hyaluronic acid complex as a 3d platform for understanding cancer cell migration in the tumor microenvironment
- 주제(키워드) 3D matrix , Migration , Multicellular spheroid , Polymer complex , Tumor microenvironment
- 후원정보 Jeong, B.; Department of Chemistry and Nanoscience, South Korea; email: bjeong@ewha.ac.kr Park, M.H.; Center for Convergence Bioceramic Materials, South Korea; email: conomo0850@gmail.com
- 등재 SCIE, SCOPUS
- 발행기관 MDPI AG
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181787
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/polym13071042
초록/요약
Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. The amphiphilic peptide block copolymer and hyaluronic acid (HA) formed a self-assembled structure, which provides a biocompatible 3D environment for the cells. Multicellular spheroids were formed on the optimized plate and were observed as cell migration from a spheroid within a 3D matrix, such as the invasive and metastatic cancer of TME. This study suggests a new 3D platform using polymer complexes and the importance of tumor complexities, including various cell types and microenvironments. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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