Dumulmycin, an antitubercular bicyclic macrolide from a riverine sediment-derived streptomyces sp.
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181906
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.orglett.1c00847
초록/요약
Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 μM). © 2021 American Chemical Society.
more