Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents
- 주제(키워드) Anti-inflammatory effect , Antioxidative effect , Neuroprotective agent , Psiguadial B , Reactive oxygen species , Short synthetic route
- 등재 SCIE, SCOPUS
- 발행기관 Academic Press Inc.
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182018
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.bioorg.2021.105027
초록/요약
Psiguadial B (8), and its fluoro- (8a), chloro- (8b), and bromo- (8c) derivatives were synthesized using a sodium acetate-catalyzed single step coupling of three components: β-caryophyllene (5), diformylphloroglucinol (11), and benzaldehyde (12). These compounds efficiently and dose-dependently decreased H2O2-induced cell death, a quantitative marker of cell death, in primary cultures of mouse cortical neurons. Psiguadial B also decreased neuronal death and accumulation of ROS induced by FeCl2 in cortical cultures. The in vitro effects of these compounds in lipopolysaccharide (LPS)-induced expression of nitric oxide (NO), and TNF-α and IL-6 by suppressing the NF-κB pathway in immune cells demonstrated their antioxidative and anti-inflammatory activity. The present findings warrant further research on the development of psiguadial B-based neuroprotective agents for the treatment of neurodegenerative diseases, acute brain injuries and immunological disorders. © 2021 Elsevier Inc.
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