Discontinuation rate of newly prescribed donepezil in alzheimer’s disease patients in asia
- 주제(키워드) Asia , Cognition , Donepezil , Alzheimer’s disease
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 Korean Neurological Association
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182131
- 본문언어 영어
- Published As http://dx.doi.org/10.3988/jcn.2021.17.3.376
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The rate of donepezil discontinuation and the underlying rea-sons for discontinuation in Asian patients with Alzheimer’s disease (AD) are currently un-known. We aimed to determine the treatment discontinuation rates in AD patients who had newly been prescribed donepezil in routine clinical practice in Asia. Methods This 1-year observational study involved 38 institutions in seven Asian countries, and it evaluated 398 participants aged 50–90 years with a diagnosis of probable AD and on newly prescribed donepezil monotherapy. The primary endpoint was the rate of donepezil discontinuation over 1 year. Secondary endpoints included the reason for discontinuation, treatment duration, changes in cognitive function over the 1-year study period, and compliance as assessed using a clinician rating scale (CRS) and visual analog scale (VAS). Results Donepezil was discontinued in 83 (20.9%) patients, most commonly due to an adverse event (43.4%). The mean treatment duration was 103.67 days in patients who discontin-ued. Among patients whose cognitive function was assessed at baseline and 1 year, there were no significant changes in scores on the Mini-Mental State Examination, Montreal Cognitive Assessment, and Trail-Making Test–Black and White scores, whereas the Clinical Dementia Rating score increased significantly (p<0.001). Treatment compliance at 1 year was 96.8% (306/316) on the CRS and 92.6±14.1% (mean±standard deviation) on the VAS. Conclusions In patients on newly prescribed donepezil, the primary reason for discontinuation was an adverse event. Cognitive assessments revealed no significant worsening at 1 year, indicat-ing that continuous donepezil treatment contributes to the maintenance of cognitive function. © 2021 Korean Neurological Association.
more