Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Bang, Yoo-Jin; Hong, So-Hee; Park, Hyo-Jung; Kwak, Hye Won; Lee, Yu-Sun; Kim, Jae-Yong; Park, Hyeong-Jun; Bae, Seo-Hyeon; Kim, Hye-Jung; Nam, Jae-Hwan] Catholic Univ Korea, Dept Med & Biol Sci, Bucheon, Gyeonggi Do, South Korea; [Bang, Yoo-Jin; Hong, So-Hee; Park, Hyo-Jung; Kwak, Hye Won; Lee, Yu-Sun; Kim, Jae-Yong; Park, Hyeong-Jun; Bae, Seo-Hyeon; Nam, Jae-Hwan] Catholic Univ Korea, BK Plus Dept Biotechnol, Bucheon, Gyeonggi Do, South Korea; [Kim, Yun-Hee; Kim, Hun] SK Biosci, Dept R&D, Pangyoro, South Korea; [Li Ko, Hae; Park, Sang-In] Scripps Korea Antibody Inst, Chunchon, Kangwon Do, South Korea; [Park, Gyeongjoo; Chang, Jun] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul, South Korea; [Park, Man-Seong] Korea Univ, Coll Med, Dept Microbiol, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 NATURE RESEARCH
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182183
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-021-91445-3
초록/요약
There is an unmet need for new influenza vaccine strategies that compensate for impaired vaccine responses in elderly individuals. Here, we evaluated the effectiveness of a single-stranded RNA (ssRNA) as an adjuvant to enhance the efficacy of inactivated influenza vaccine (IIV) in mouse models. Immunization with the ssRNA along with IIV reduced viral titers as well as pathological and inflammatory scores in the lungs after influenza challenge in aged mice. ssRNA induced balanced Th1/Th2 responses with an increase in IgA titers. Moreover, the ssRNA adjuvant markedly increased the frequency of influenza HA-specific T cells and IFN-gamma production along with the expression of genes related to innate and adaptive immune systems that could overcome immunosenescence in aged mice. Our findings indicate that ssRNA is an efficient vaccine adjuvant that boosts cellular and humoral immunity in aged mice, demonstrating its potential as a novel adjuvant for currently available influenza virus vaccines for elderly individuals.
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