Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy
- 주제(키워드) Fe(II)-coordination-driven Co-assembly , photosensitizer , self-evolution , photosensitive nanoparticles , ferrotherapeutic agent
- 주제(기타) Nanoscience & Nanotechnology
- 주제(기타) Materials Science, Multidisciplinary
- 설명문(일반) [Han, Jingjing; Kwon, Nahyun; Li, Haidong; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Kang, Hyunchul; Park, Sungnam] Korea Univ, Dept Chem, Seoul 02841, South Korea; [Li, Xingshu] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182227
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acsanm.1c00843
초록/요약
Nanoparticle-based enzyme mimics have fewer applications in ferrotherapy so far. The limited number of integrated biomimetic architectures satisfy biobuilding blocks and adaptability in the high efficiency of ferrotherapy requirements. Herein, we develop a minimal nanoparticle as an efficient photodynamic ferrotherapy agent, which is constructed through ferrous-coordination-driven cyanine-based amino acid assembly. In comparison with a free photosensitizer, this nanoparticle (photo-fenozyme) composed of Fe-containing cores and serum protein shells is fabricated. And it has a high light-harvesting ability, and a higher intersystem crossing (ISC) rate constant (4.41 X 10(11) s(-1) versus 1.17 x 10(6) s(-1)), which benefits efficient production of the triplet state. The photofenozyme allows adaptive photo-Fentonlike activity based on the different radical generations. And they further trigger and photoenhance efficient ferroptosis. This work provides insights into optimizing current photosensitizers to generate an adaptive supramolecular photocatalyst and presents a promising strategy to design multifunctional nanozyme theranostics.
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