Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry
- 주제(키워드) Liver transplantation , Incidence , Risk factors , Renal insufficiency
- 주제(기타) Gastroenterology & Hepatology
- 설명문(일반) [Kim, Jong Man] Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Sch Med, Seoul, South Korea; [Kim, Deok Gie] Yonsei Univ, Dept Surg, Wonju Coll Med, Wonju, South Korea; [Kim, Jihyun; Lee, Keunsung] Novartis Korea Ltd, Seoul, South Korea; [Lee, Kwang-Woong; Cho, Jai Young] Seoul Natl Univ, Dept Surg, Coll Med, Seoul, South Korea; [Ryu, Je Ho] Pusan Natl Univ, Sch Med, Dept Surg,Yangsan Hosp, Div Hepatobiliary Pancreat Surg & Liver Transplan, Yangsan, South Korea; [Kim, Bong-Wan] Ajou Univ, Dept Liver Transplantat & Hepatobiliary Surg, Sch Med, Suwon, South Korea; [Choi, Dong Lak] Catholic Univ Daegu, Dept Surg, Coll Med, Daegu, South Korea; [You, Young Kyoung] Catholic Univ Korea, Coll Med, Dept Surg, Seoul, South Korea; [Kim, Dong-Sik] Korea Univ, Dept Surg, Div HBP Surg & Liver Transplantat, Coll Med, Seoul, South Korea; [Nah, Yang Won] Univ Ulsan, Ulsan Univ Hosp, Dept Surg, Coll Med, Ulsan, South Korea; [Kang, Koo Jeong] Keimyung Univ, Dongsan Med Ctr, Dept Surg, Sch Med, Daegu, South Korea; [Hong, Geun] Ewha Womans Univ, Mokdong Hosp, Dept Surg, Sch Med, Seoul, South Korea; [Yu, Hee Chul] Jeonbuk Natl Univ, Dept Surg, Med Sch, Jeonju, South Korea; [Moon, Ju Ik] Konyang Univ Hosp, Dept Surg, Konyang, South Korea; [Choi, Dongho] Hanyang Univ, Dept Surg, Coll Med, Seoul, South Korea; [Hwang, Shin] Univ Ulsan, Asan Med Ctr, Dept Surg, Coll Med, 88 Olymp Ro 43 Gil, Seoul 0505, South Korea; [Kim, Myoung Soo] Yonsei Univ, Dept Surg, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN ASSOC STUDY LIVER
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182242
- 본문언어 영어
- Published As http://dx.doi.org/10.3350/cmh.2020.0292
초록/요약
Background/Aims: To analyze the incidence and risk factors of outcomes after liver transplantation (LT) in the Korean population. Methods: This study analyzed data from the liver cohort of Korean Organ Transplantation Registry (KOTRY) who had LT between May 2014 and December 2017. Study measures included the incidence of post-LT outcomes in recipients of living donor LT (LDLT) and deceased donor LT (DDLT). Cox multivariate proportional hazards model was used to determine the potential risk factors predicting the outcomes. Results: A total of 2,563 adult recipients with LT (LDLT, n=1,956; DDLT, n= 607) were included, with mean +/- standard deviation age of 53.9 +/- 8.9 years, and 72.2% were male. The post-LT outcomes observed in each LDLT and DDLT recipients were death (4.0% and 14.7%), graft loss (5.0% and 16.1%), rejection (7.0% and 12.0%), renal failure (2.7% and 13.8%), new onset of diabetes (12.5% and 15.4%), and hepatocellular carcinoma (HCC) recurrence (both 6.7%). In both LDLT and DDLT recipients, the most common post-LT complications were renal dysfunction (33.6% and 51.4%), infection (26.7% and 48.4%), and surgical complication (22.5% and 23.9%). Incidence of these outcomes were generally higher among recipients of DDLT than LDLT. Multivariate analysis indicated recipient age and DDLT as significant risk factors associated with death and graft loss. DDLT and ABO incompatible transplant were prognostic factors for rejection, and HCC beyond Milan criteria at pre-transplant was a strong predictor of HCC recurrence. Conclusions: This study is a good indicator of the post-LT prognosis in the Korean population and suggests a significant burden of post-LT complications.
more