Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
- 주제(키워드) Angioplasty , Mortality , Paclitaxel , Peripheral arterial occlusive disease , Stents
- 주제(기타) Surgery
- 설명문(일반) [Choi, Hyunsook; Lee, Haine; Lee, Sang-Soo] Medtron Korea Ltd, Healthcare Econ & Govt Affairs, Seoul, South Korea; [Choi, Hyunsook; Ahn, Jeonghoon] Ehwa Womans Univ, Dept Hlth Convergence, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Joh, Jin Hyun] Kyung Hee Univ, Dept Surg, Kyung Hee Univ Hosp Gangdong, Sch Med, Seoul, South Korea; [Lee, Moo-Yeol] Chung Ang Univ, Dept Physiol, Sch Med, Seoul, South Korea; [Choi, Hyunsook; Lee, Sang-Soo] Sungkyunkwan Univ, Dept Med Device Management & Res, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SURGICAL SOCIETY
- 발행년도 2021
- URI http://www.dcollection.net/handler/ewha/000000182268
- 본문언어 영어
- Published As http://dx.doi.org/10.4174/astr.2021.101.1.20
초록/요약
Purpose: Drug-coated devices have been widely accepted as one of the most promising therapies for femoropopliteal artery revascularization. A recent meta-analysis showed increased mortality in patients treated with drug-coated devices. We sought to examine the association between mortality and drug-coated devices after the treatment of the femoropopliteal artery based on the Korea national administrative claims data. Methods: In the National Health Insurance Service database from August 2015 to December 2017, we identified patients with femoropopliteal artery revascularization using percutaneous transluminal angioplasty (PTA), bare metal stents (BMS), drug-coated balloon (DCB), or drug-eluting stents (DES). Kaplan-Meier methods were used to estimate the survival among devices, and log-rank tests were used to evaluate differences between groups. Adjusted hazard ratios (aHRs) were computed using the inverse probability of treatment weightings (IPTW). Results: There were 1,724 patients (mean age, 70.9 +/- 10.7 years; male, 1,350 [78.3%]) included in the analysis. The median follow-up period was 552 days (interquartile range, 404-688 days). There was a difference in IPTW-adjusted mortality risk among device types (26.3% in PTA, 22.1% in BMS, 17.7% in DCB, and 17.8% in DES; P = 0.004). IPTW-adjusted Cox proportional hazard analysis showed that drug-coated devices were associated with decreased all-cause mortality risk (aHR, 0.70; 95% confidence interval, 0.58-0.86). Conclusion: Our real-world analysis showed that there was no evidence of increased all-cause mortality after femoropopliteal artery revascularization with drug-coated devices compared with non-drug-coated devices. [Ann Surg Treat Res 2021;101(1):20-27]
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