Rational Design of Meso-Phosphino-Substituted BODIPY Probes for Imaging Hypochlorite in Living Cells and Mice
- 주제(기타) Chemistry, Analytical
- 설명문(일반) [Ma, Chunyu; Hou, Shumin; Zhou, Xin; Wang, Zonghua] Qingdao Univ, Coll Chem & Chem Engn, Dept Chem, Qingdao 266071, Peoples R China; [Wang, Zonghua] Qingdao Univ, Instrumental Anal Ctr, Shandong Sino Japanese Ctr Collaborat Res Carbon, Qingdao 266071, Peoples R China; [Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182289
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.analchem.1c02025
초록/요약
Meso-phosphino-substituted BODIPY probes were developed for concise and rapid detection of hypochlorite (ClO-). Interestingly, the probe BP gave a turn-on fluorescence response by shutting the photoinduced electron transfer (PET) effect and extending the coplanar conjugated pi-system. In contrast, the probe TMBP showed a colorimetric response toward ClO-. The key role of the steric repulsions was revealed to be for altering the electronic distribution of the BODIPY core, resulting in these obviously different responses. Finally, the probe BP, with high selectivity and sensitivity toward ClO- (LOD = 1.9 nM; response time, <15 s), was further employed in imaging the variations of exogenous and endogenous hypochlorite (ClO-) in living RAW 264.7 cells and mouse inflammation models. If wisely utilized, this strategy with mesophosphino BODIPY dyes may serve as a powerful platform for the preparation of novel chemosensors.
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