Association between Influenza Vaccination and the Risk of Bell's Palsy in the Korean Elderly
- 주제(키워드) influenza vaccine , Bell's palsy , elderly people , adverse events , large-linked database , self-controlled risk interval design
- 주제(기타) Immunology
- 주제(기타) Medicine, Research & Experimental
- 설명문(일반) [Jeong, Nayoung; Choi, Namkyong] Ewha Womans Univ, Dept Hlth Convergence, Seoul 03760, South Korea; [Kim, Yejee] Univ Ulsan, Asan Med Ctr, Dept Clin Epidemiol & Biostat, Coll Med, Seoul 05505, South Korea; [Kim, Chungjong] Ewha Womans Univ, Dept Internal Med, Seoul Hosp, Seoul 07804, South Korea; [Park, Sangmin] Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea; [Park, Sangmin] Seoul Natl Univ, Seoul Natl Univ Grad Sch, Dept Biomed Sci, Coll Med, Seoul 03080, South Korea; [Lee, Joongyub] Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul 03080, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- URI http://www.dcollection.net/handler/ewha/000000182322
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/vaccines9070746
초록/요약
Previous studies have shown controversial results on the risk of Bell's palsy after influenza vaccination. Since the antigenic components of influenza vaccine can vary from season to season, continuous safety monitoring is required. The aim of the present study was to determine whether there was an increased risk of Bell's palsy in the elderly after influenza vaccination between the 2015/2016 and 2017/2018 flu seasons. This study included the elderly who received influenza vaccinations for three flu seasons using a large-linked database of vaccination registration data from the Korea Disease Control and Prevention Agency and the National Health Insurance Service claims data. We used a self-controlled risk interval design with a risk interval of 1 to 42 days and a control interval of 57 to 98 days postvaccination and calculated the incidence rate ratio. To ensure the robustness of the results, sensitivity analyses were also carried out with different risk and control intervals. Of 4,653,440 elderly people who received the influenza vaccine, there was no statistically significant increase in the risk of Bell's palsy (IRR: 0.99, 95% CI: 0.92-1.07). Similar results were found in analysis results for each season and the results of the sensitivity analyses excluding the 2017/2018 season. In conclusion, we found no evidence of an increased risk of Bell's palsy after influenza vaccination. The results of our study provide reassurance about the safety of the influenza vaccine NIP program. However, it is necessary to continuously monitor the risk of Bell's palsy during future flu seasons.
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