Joint association of prenatal bisphenol-A and phthalates exposure with risk of atopic dermatitis in 6-month-old infants
- 주제(키워드) Phthalates , Atopic dermatitis , Prospective birth cohort , Bayesian kernel machine regression model , Multi-pollutant effect , Prenatal exposure , Bisphenol A
- 주제(기타) Environmental Sciences
- 설명문(일반) [Lee, Seulbi; Ha, Eunhee] Ewha Womans Univ, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea; [Lee, Seulbi; Park, Sung Kyun] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI USA; [Park, Sung Kyun] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI USA; [Park, Hyesook] Ewha Womans Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Park, Hyesook; Ha, Eunhee] Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea; [Lee, Woojoo] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth Sci, Seoul, South Korea; [Lee, Ji Hyen] Ewha Womans Univ, Coll Med, Dept Pediat, Seoul, South Korea; [Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Ha, Mina] Dankook Univ, Coll Med, Dept Prevent Med, Cheonan, South Korea; [Kim, Yangho] Univ Ulsan, Coll Med, Dept Occupat & Environm Med, Ulsan Univ Hosp, Ulsan, South Korea; [Lee, Bo-Eun] Natl Inst Environm Res, Environm Hlth Res Div, Incheon, South Korea; [Ha, Eunhee] Ewha Womans Univ, Coll Med, Ewha Med Res Inst, Seoul, South Korea; [Ha, Eunhee] 25 Magokdong Ro 2 Gil, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182327
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.scitotenv.2021.147953
초록/요약
Background: Prenatal exposure to bisphenol A (BPA) and phthalates could trigger immune response. Few studies have investigated the association between prenatal BPA and phthalate exposure and atopic dermatitis (AD) in infants. Objective: We aimed to clarify the joint association of prenatal exposure to BPA and phthalate metabolites with AD incidence in 6-month-old infants. Methods: We included 413 mother-child pairs from the Mothers and Children's Environmental Health (MOCEH) in a prospective birth cohort study. Maternal urinary BPA, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), and mono-n-butyl phthalate (MnBP) concentrations were measured during early and late pregnancy. We applied the Bayesian kernel machine regression (BKMR) with probit regression to estimate the association of BPA and phthalate metabolites with AD incidence after adjusting for potential confounders. Individual association was estimated by differences in predicted probabilities comparing each individual chemical concentration at 75th versus 25th percentiles, while other chemicals were set at their median. Overall joint effect was estimated by differences in predicted probabilities comparing all chemical concentrations at 75th versus 25th percentiles. Results: Individual effect of MEHHP in late pregnancy was strongly associated with incident AD [Difference: 0.244 (95% credible interval: -0.066, 0.554)] in the model including both early and late exposures. Furthermore, we confirmed overall joint association of urinary BPA and phthalate metabolites during pregnancy with a higher risk of AD [0.347 (0.168, 0.526) for late pregnancy exposure, and 0.307 (0.094, 0.521) for both early and late pregnancy]. Additionally, the joint association was more prominent among girls than that in boys. Conclusions: The joint association of prenatal exposure to BPA and phthalates could be associated with the incident AD in 6-month-old infants. Further studies are needed to confirm the synergistic effect of BPA and phthalate exposures on AD in children. (c) 2021 Elsevier B.V. All rights reserved.
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