The risk of preterm birth in vanishing twin: A multicenter prospective cohort study
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Seong, Ji Su; Park, Chan-Wook; Park, Joong Shin; Jun, Jong Kwan; Lee, Seung Mi] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; [Han, You Jung; Oh, Soo-young; Lee, Joon Ho] CHA Univ, Dept Obstet & Gynecol, CHA Gangnam Med Ctr, Seoul, South Korea; [Kim, Min Hyoung] MizMedi Hosp, Dept Obstet & Gynecol, Seoul, South Korea; [Shim, Jae-Yoon; Lee, Mi-Young] Univ Ulsan, Coll Med, Dept Obstet & Gynecol, Asan Med Ctr, Seoul, South Korea; [Shim, Jae-Yoon] Mirae & Heemang Obstet & Gynecol Clin, Seoul, South Korea; [Oh, Soo-young] Sungkyunkwan Univ, Dept Obstet & Gynecol, Samsung Med Ctr, Sch Med, Seoul, South Korea; [Lee, Joon Ho] Yonsei Univ, Yonsei Univ Hlth Syst, Inst Womens Life Med Sci, Dept Obstet & Gynecol,Coll Med, Seoul, South Korea; [Cho, Geum Joon] Korea Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; [Kwon, Han-Sung] Konkuk Univ, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; [Kim, Byoung Jae] Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Obstet & Gynecol, Seoul, South Korea; [Park, Mi Hye] Ewha Womans Univ, Dept Obstet & Gynecol, Seoul, South Korea; [Cho, Hee Young; Ryu, Hyun Mee] CHA Univ, Bundang CHA Hosp, Dept Obstet & Gynecol, Pocheon Si, South Korea; [Ko, Hyun Sun] Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 PUBLIC LIBRARY SCIENCE
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182435
- 본문언어 영어
- Published As http://dx.doi.org/10.1371/journal.pone.0233097
- PubMed https://pubmed.ncbi.nlm.nih.gov/32470065
초록/요약
Objective To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT). Study design This is a secondary analysis of a multicenter prospective cohort study. In 12 different health-care institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery. Results A total of 4,746 women were included in the final analysis, and. the frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception. Conclusion Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.
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