Harnessing the bioresponsive adhesion of immuno-bioglue for enhanced local immune checkpoint blockade therapy
- 주제(키워드) Immune checkpoint blockade , Mussel adhesive protein , Localized immunotherapy , Combination cancer immunotherapy , Anti-PD-L1
- 주제(기타) Engineering, Biomedical
- 주제(기타) Materials Science, Biomaterials
- 설명문(일반) [Joo, Kye Il; Jeong, Yeonsu; Shin, Mincheol; Lee, Jaeyun; Cha, Hyung Joon] Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 37673, South Korea; [Hwang, Sung-Min; Lee, Haena; Im, Sin-Hyeog] Pohang Univ Sci & Technol, Div Integrat Biosci & Biotechnol, Pohang 37673, South Korea; [Sharma, Garima] ImmunoBiome Inc, POSTECH Biotech Ctr, Pohang 37673, South Korea; [Im, Sin-Hyeog] Pohang Univ Sci & Technol, Dept Life Sci, Pohang 37673, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCI LTD
- 발행년도 2020
- URI http://www.dcollection.net/handler/ewha/000000182510
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.biomaterials.2020.120380
초록/요약
Despite the great promise of immune checkpoint blockade (ICB) therapy for cancer treatment, the currently available options for ICB treatment pose major clinical challenges, including the risk of severe systemic autoimmune responses. Here, we developed a novel localized delivery platform, immuno-bioglue (imuGlue), which is inspired by the intrinsic underwater adhesion properties of marine mussels and can allow the optimal retention of anti-PD-L1 drugs at tumor sites and the on-demand release of drugs in response to the tumor microenvironment. Using a triple-negative breast cancer and melanoma models, we found that imuGlue could significantly enhance anti-tumor efficacy by eliciting a robust T cell-mediated immune response while reducing systemic toxicity by preventing the rapid diffusion of anti-PD-L1 drugs into the systemic circulation and other tissues. It was also demonstrated that imuGlue could be successfully utilized for combination therapy with other immunomodulatory drugs to enhance the anti-tumor efficacy of ICB-based immunotherapy, demonstrating its versatility as a new treatment option for cancer immunotherapy.
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