Activation of beta(2) adrenergic receptor signaling modulates inflammation: a target limiting the progression of kidney diseases
- 주제(키워드) β , (2)-Adrenergic receptors , β , (2)-Agonist , Cyclic AMP , GPCR , Inflammation , Kidney diseases
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Dorotea, Debra; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 PHARMACEUTICAL SOC KOREA
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182513
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-020-01280-9
- PubMed https://pubmed.ncbi.nlm.nih.gov/33155167
초록/요약
Beta 2 adrenergic receptor (beta(2)-AR)-agonists, widely used as bronchodilators, have demonstrated wide-spectrum anti-inflammatory properties in both immune and non-immune cells in various tissues. Their anti-inflammatory properties are mediated primarily, but not exclusively, via activation of the canonical beta(2)-AR signaling pathway (beta(2)-AR/cAMP/PKA). As non-canonical beta(2)-AR signaling also occurs, several inconsistent findings on the anti-inflammatory effect of beta(2)-agonists are notably present. Increasing amounts of evidence have unveiled the alternative mechanisms of the beta(2)-AR agonists in protecting the tissues against injuries, i.e., by augmenting mitochondria biogenesis and SIRT1 activity, and by attenuating fibrotic signaling. This review mainly covers the basic mechanisms of the anti-inflammatory effects of beta(2)-AR activation along with its limitations. Specifically, we summarized the role of beta(2)-AR signaling in regulating kidney function and in mediating the progression of acute and chronic kidney diseases. Given their versatile protective effects, beta(2)-agonists can be a promising avenue in the treatment of kidney diseases.
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