Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation
- 주제(키워드) azelaic acid , C. elegans , fatty acid desaturation , lifespan
- 주제(기타) Chemistry, Multidisciplinary
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Bai, Juan] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China; [Bai, Juan; Jang, Miran; Zhang, Yuan; Kim, Kee-Hong] Purdue Univ, Dept Food Sci, W Lafayette, IN 47907 USA; [Farias-Pereira, Renalison; Park, Yeonhwa] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA; [Zhang, Yuan] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China; [Lee, Sang Mi; Kim, Young-Suk] Ewha Womans Univ, Dept Food Sci & Engn, Seoul 120750, South Korea; [Ahn, Jun Bae] Seowon Univ, Dept Food Serv & Culinary Arts, Cheongju 361742, South Korea; [Kim, Gun-Hee] Duksung Womens Univ, Dept Food & Nutr, Seoul 01370, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER/PLENUM PUBLISHERS
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182522
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s11095-020-02975-w
- PubMed https://pubmed.ncbi.nlm.nih.gov/33449249
초록/요약
Purpose Azelaic acid (AzA) is a dicarboxylic acid naturally occurring in various grains having anti-inflammatory and anti-oxidation properties. Recently, AzA is shown to reduce high-fat diet-induced adiposity in animals. However, its physiological role in lipid metabolism and aging in various environmental stresses is unknown. Methods and Results Using C. elegans as an invertebrate animal model, we demonstrate that AzA suppresses fat accumulation with no effect on lifespan at normal temperatures. Moreover, AzA promotes lifespan at low temperatures by elevation of unsaturated long-chain fatty acids and expression of genes in fatty acid desaturation. We further find that genes encoding fatty acid desaturases such as fat-1, fat-5, fat-6, and fat-7 are crucial for the lifespan-extending effect of AzA at low temperature. Conclusions Taken together, our results suggest that AzA promotes adaption to low temperature in C. elegans via shifting fatty acid profile to unsaturated long-chain fatty acids.
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