Evaluation of statistical methods for the analysis of crossover designs with repeated measurements
- 주제(키워드) correlated data , crossover design , mixed effects model , generalised estimating equation model , local odds ratio
- 주제(기타) Mathematical & Computational Biology
- 설명문(일반) [Kamruzzaman, Md; Kim, Yonggab; Park, Taesung] Seoul Natl Univ, Dept Stat, Seoul, South Korea; [Lim, Yeni] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul, South Korea; [Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 INDERSCIENCE ENTERPRISES LTD
- 발행년도 2021
- URI http://www.dcollection.net/handler/ewha/000000183274
- 본문언어 영어
- Published As http://dx.doi.org/10.1504/IJDMB.2021.116889
초록/요약
The crossover design is a type of longitudinal study used in clinical trials to evaluate the effectiveness of new drugs and new treatments. In the crossover design, each subject is subsequently switched through all treatments after a washout period. Although the linear mixed-effects model is one of the commonly used methods for crossover designs, sometimes it suffers from convergence problems. In this study, we adopted generalised estimating equations for crossover design by shifting the position of the variables so that the independent variables of the linear mixed models are regarded as the response variables. The advantage of the generalised estimating equation model lies in its simple computation and is relatively easy to use. A simulation study showed that the power of generalised estimating equation models is comparable to or slightly better than that of linear mixed-effects model.
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