Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study
- 주제(키워드) Alzheimer's disease , APOE , genome-wide association study , late-onset Alzheimer's disease , stratified genome analysis
- 주제(기타) Neurosciences
- 설명문(일반) [Kang, Sarang; Gim, Jungsoo; Gunasekaran, Tamil Iniyan; Choi, Kyu Yeong; Lee, Jang Jae; Seo, Eun Hyun; Chung, Ji Yeon; Choi, Seong-Min; Song, Min Kyung; Kim, Hoowon; Kim, Byeong C.; Lee, Kun Ho] Chosun Univ, Gwangju Alzheimers & Related Dementias Cohort Res, Gwangju, South Korea; [Kang, Sarang; Gim, Jungsoo; Lee, Kun Ho] Chosun Univ, Dept Integrat Biol Sci, Gwangju, South Korea; [Gim, Jungsoo; Lee, Kun Ho] Neurozen Inc, Seoul, South Korea; [Gim, Jungsoo; Lee, Jiwoon; Gunasekaran, Tamil Iniyan; Lee, Kun Ho] Chosun Univ, Dept Biomed Sci, Gwangju 61452, South Korea; [Seo, Eun Hyun] Chosun Univ, Dept Premed Sci, Coll Med, Gwangju, South Korea; [Ko, Pan-Woo; Lee, Ho-Won] Kyungpook Natl Univ, Dept Neurol, Sch Med, Daegu, South Korea; [Chung, Ji Yeon; Kim, Hoowon] Chosun Univ Hosp, Dept Neurol, Gwangju, South Korea; [Choi, Seong-Min; Kim, Byeong C.] Chonnam Natl Univ, Dept Neurol, Med Sch, Gwangju, South Korea; [Lee, Young Min] Pusan Natl Univ, Dept Psychiat, Sch Med, Busan, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, Mokdong Hosp, Seoul, South Korea; [Park, Kyung Won] Dong A Univ, Dept Neurol, Coll Med, Busan, South Korea; [Song, Min Kyung] Chonnam Natl Univ, Gwangju Geriatr Hosp 2, Gwangju, South Korea; [Kim, Ki Woong] Seoul Natl Univ, Dept Neuropsychiat, Bundang Hosp, Seongnam, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea; [Lee, Dong Young] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea; [Kim, Sang Yun] Seoul Natl Univ, Dept Neurol, Bundang Hosp, Seongnam, South Korea; [Ikeuchi, Takeshi] Niigata Univ, Brain Res Inst, Dept Mol Genet, Niigata, Japan; [Lee, Kun Ho] Korea Brain Res Inst, Daegu, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 IOS PRESS
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183454
- 본문언어 영어
- Published As http://dx.doi.org/10.3233/JAD-210145
초록/요약
The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE epsilon 4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer's and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: PRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.
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