Peroxiredoxins as Potential Targets for Cardiovascular Disease
- 주제(키워드) antioxidant enzymes , aneurysm , atherosclerosis , cardiovascular diseases , hydrogen peroxide , oxidative stress , peroxiredoxins , reactive oxygen species
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology
- 설명문(일반) [Jeong, Se-Jin] Washington Univ, Ctr Cardiovasc Res, Sch Med, St Louis, MO 63110 USA; [Park, Jong-Gil] Korea Res Inst Biosci & Biotechnol KRIBB, Biotherapeut Translat Res Ctr, 125 Gwahak Ro, Daejeon 34141, South Korea; [Oh, Goo Taeg] Ewha Womans Univ, Heart Immune Brain Network Res Ctr, Dept Life Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183466
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/antiox10081244
초록/요약
Increased oxidative stress (OS) is considered a common etiology in the pathogenesis of cardiovascular disease (CVD). Therefore, the precise regulation of reactive oxygen species (ROS) in cardiovascular cells is essential to maintain normal physiological functions. Numerous regulators of cellular homeostasis are reportedly influenced by ROS. Hydrogen peroxide (H2O2), as an endogenous ROS in aerobic cells, is a toxic substance that can induce OS. However, many studies conducted over the past two decades have provided substantial evidence that H2O2 acts as a diffusible intracellular signaling messenger. Antioxidant enzymes, including superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins (Prdxs), maintain the balance of ROS levels against augmentation of ROS production during the pathogenesis of CVD. Especially, Prdxs are regulatory sensors of transduced intracellular signals. The intracellular abundance of Prdxs that specifically react with H2O2 act as regulatory proteins. In this review, we focus on the role of Prdxs in the regulation of ROS-induced pathological changes in the development of CVD.
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