Animal model of intestinal anti-inflammatory effect of ginger-cinnamon complex
- 주제(키워드) Ginger , Cinnamon , Extract mixtures , Intestine , Anti-inflammatory
- 주제(기타) Food Science & Technology
- 설명문(일반) [Im, Jin A.; Kim, Min Seo; Kim, Ji Yeon] Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, 232 Gongneung Ro, Seoul 01811, South Korea; [Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea; [Shin, Jae-Ho] Eulji Univ, Dept Biomed Lab Sci, Seongnam Si 13135, Gyeonggi Do, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- 발행년도 2021
- URI http://www.dcollection.net/handler/ewha/000000183506
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10068-021-00965-1
초록/요약
This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL), and high GE + CSWE (GCH) for 21 days and drinking water containing 5% DSS for the final 7 days to induce intestinal inflammation. We assessed the change of body weight, disease activity index (DAI), histopathological scores, myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showed increased body weight, inhibited intestinal shortening, and decreased DAI and histopathological score of intestinal inflammation, which was similar to that for the control group. It inhibited MPO activity as well as interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha mRNA levels. Therefore, the ginger-cinnamon complex helps to improve intestine inflammation, which is beneficial for gut health.
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