Clinical Significance of Variable Histomorphologic Findings Related to Mucosal Inflammation in Negative Appendectomy
- 주제(키워드) negative appendectomy , appendicitis inflammatory response (AIR) score , mucosal inflammation , high neutrophil score , surface epithelial flattening
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Choi, Euno; Kim, Ji Min; Sung, Sun Hee; Park, Sanghui] Ewha Womans Univ, Dept Pathol, Coll Med, Seoul 07985, South Korea; [Yoo, Youngeun] Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul 05505, South Korea; [Lee, Dakeun] Ajou Univ, Dept Pathol, Sch Med, Suwon 16499, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183531
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm10174030
초록/요약
The aim of the study was to investigate the clinical significance of various histomorphologic findings related to mucosal inflammation in negative appendectomy. We reviewed histopathologic findings of 118 negative appendectomies and correlated them with the appendicitis inflammatory response (AIR) score and appendiceal diameter. Among 118 patients with negative appendectomy, 94 (80%), 73 (78%) and 89 (75%) patients displayed mucosal inflammation, high neutrophil score (neutrophil count >= 10/5 high power field and surface epithelial flattening, respectively. Out of 118 patients with negative appendectomy, mucosal inflammation, high neutrophil score and surface epithelial flattening were associated with higher risk group according to the appendicitis inflammatory response (AIR) score (p < 0.05, respectively). In addition, mucosal inflammation, high neutrophil score and surface epithelial flattening were frequently detected in 118 negative appendectomies, compared with 24 incidental appendectomies (p < 0.05, respectively). In an analysis of 77 negative appendectomy patients with appendiceal diameter data available, increased appendiceal diameter was positively correlated with luminal inflammation, high neutrophil score and surface epithelial flattening (p < 0.05, respectively). In conclusion, mucosal inflammation, high neutrophil score and surface epithelial flattening in negative appendectomy may be relevant to patients' signs and symptoms, especially in cases with no other cause of the abdominal pain.
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