Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019
- 주제(키워드) Streptococcus pneumoniae , Serotype , Genotype , Children
- 주제(기타) Immunology; Medicine, Research & Experimental
- 설명문(일반) [Yun, Ki Wook; Rhie, Kyuyol; Lee, Hyunju; Lee, Hoan Jong; Choi, Eun Hwa] Seoul Natl Univ, Coll Med, Seoul, South Korea; [Kang, Jin Han] Catholic Univ Korea, Coll Med, Seoul, South Korea; [Kim, Kyung-Hyo] Ewha Womans Univ, Sch Med, Seoul, South Korea; [Ahn, Jong Gyun] Yonsei Univ, Coll Med, Seoul, South Korea; [Kim, Yae-Jean] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea; [Eun, Byung Wook] Nowon Eulji Univ Hosp, Seoul, South Korea; [Oh, Sung Hee] Hanyang Univ, Coll Med, Seoul, South Korea; [Cho, Hye-Kyung] Gachon Univ, Gil Med Ctr, Coll Med, Incheon, South Korea; [Hong, Young Jin] Inha Univ, Sch Med, Incheon, South Korea; [Kim, Nam Hee] Inje Univ, Ilsan Paik Hosp, Goyang, South Korea; [Kim, Yun-Kyung] Korea Univ, Coll Med, Seoul, South Korea; [Lee, Hyunju] Seoul Natl Univ, Bundang Hosp, Seoul, South Korea; [Lee, Taekjin] CHA Univ, CHA Bundang Med Ctr, Seongnam, South Korea; [Kim, Hwang Min] Yonsei Univ, Wonju Coll Med, Wonju, South Korea; [Cho, Eun Young] Chungnam Natl Univ Hosp, Daejeon, South Korea; [Kim, Chun Soo] Keimyung Univ, Sch Med, Daegu, South Korea; [Park, Su Eun] Pusan Natl Univ, Sch Med, Yangsan, South Korea; [Oh, Chi Eun] Kosin Univ, Coll Med, Busan, South Korea; [Jo, Dae Sun] Jeonbuk Natl Univ, Med Sch, Jeonju, South Korea; [Song, Eun Song] Chonnam Natl Univ, Med Sch, Gwangju, South Korea; [Lee, Jina] Univ Ulsan, Coll Med, Seoul, South Korea; [Choi, Jae Hong] Jeju Natl Univ, Sch Med, Jeju, South Korea; [Lee, Joon Kee] Chungbuk Natl Univ Hosp, Cheongju, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCI LTD
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183570
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.vaccine.2021.08.072
- PubMed https://pubmed.ncbi.nlm.nih.gov/34465475
초록/요약
Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014-2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most com-mon serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant. (c) 2021 Elsevier Ltd. All rights reserved.
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