Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp.
- 주제(키워드) Didemnum , antibacterial , colonial tunicate , bicyclic fatty acids
- 주제(기타) Chemistry, Medicinal; Pharmacology & Pharmacy
- 설명문(일반) [Kim, Hiyoung; Wang, Weihong; Lee, Jusung; Kang, Heonjoong] Seoul Natl Univ, Sch Earth & Environm Sci, Lab Marine Drugs, NS-80, Seoul 08826, South Korea; [Kim, Hiyoung] Konkuk Univ, Dept Biomed Sci & Engn, Seoul 05029, South Korea; [Lee, Tae Gu] FarmHannong Co Ltd, Crop Protect Res Inst, Safety Res Team, Nonsan 33010, South Korea; [Yang, Inho] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea; [Wang, Weihong; Kang, Heonjoong] Seoul Natl Univ, Res Inst Oceanog, Seoul 08826, South Korea; [Chin, Jungwook] Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; [Rho, Boon Jo] Ewha Womans Univ, Nat Hist Museum, Seoul 03760, South Korea; [Choi, Hyukjae] Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; [Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Hahn, Dongyup] Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; [Hahn, Dongyup] Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; [Kang, Heonjoong] Seoul Natl Univ, Interdisciplinary Grad Program Genet Engn, NS-80, Seoul 08826, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183598
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/md19090521
- PubMed https://pubmed.ncbi.nlm.nih.gov/34564183
초록/요약
Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (1-3), and the other two were dicarboxylic derivatives (4 and 5). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound 2 exhibited the most potent antibacterial activity (MIC, 2 mu g/mL).
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