Ellagic Acid Prevents Binge Alcohol-Induced Leaky Gut and Liver Injury through Inhibiting Gut Dysbiosis and Oxidative Stress
- 주제(키워드) binge alcohol , ellagic acid , gut microbiota , intestinal barrier dysfunction , endotoxemia , inflammatory fatty liver injury
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology
- 설명문(일반) [Kim, Dong-ha; Sim, Yejin; Hwang, Jin-hyeon; Kwun, In-Sook; Cho, Young-Eun] Andong Natl Univ, Dept Food & Nutr, Andong 36729, South Korea; [Lim, Jae-Hwan] Andong Natl Univ, Dept Biol Sci, Andong 36729, South Korea; [Kim, Jihoon] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA; [Kim, Jee-In] Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; [Baek, Moon-Chang] Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Mol Med, Daegu 41944, South Korea; [Akbar, Mohammed] Natl Inst Alcohol Abuse & Alcoholism, Div Neurosci & Behav, Bethesda, MD 20892 USA; [Seo, Wonhyo] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul 03760, South Korea; [Kim, Do-Kyun] Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan 54531, South Korea; [Song, Byoung-Joon] NIAAA, Natl Inst Hlth Bethesda, Lab Membrane Biochem & Biophys, Sect Mol Pharmacol & Toxicol, Bethesda, MD 20892 USA
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183601
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.fct.2013.09.003; 10.1074/jbc.M510644200; 10.3390/antiox10091386
- PubMed https://pubmed.ncbi.nlm.nih.gov/34573017
초록/요약
Alcoholic liver disease (ALD) is a major liver disease worldwide and can range from simple steatosis or inflammation to fibrosis/cirrhosis, possibly through leaky gut and systemic endotoxemia. Many patients with alcoholic steatohepatitis (ASH) die within 60 days after clinical diagnosis due to the lack of an approved drug, and thus, synthetic and/or dietary agents to prevent ASH and premature deaths are urgently needed. We recently reported that a pharmacologically high dose of pomegranate extract prevented binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. Herein, we investigate whether a dietary antioxidant ellagic acid (EA) contained in many fruits, including pomegranate and vegetables, can protect against binge alcohol-induced leaky gut, endotoxemia, and liver inflammation. Pretreatment with a physiologically-relevant dose of EA for 14 days significantly reduced the binge alcohol-induced gut barrier dysfunction, endotoxemia, and inflammatory liver injury in mice by inhibiting gut dysbiosis and the elevated oxidative stress and apoptosis marker proteins. Pretreatment with EA significantly prevented the decreased amounts of gut tight junction/adherent junction proteins and the elevated gut leakiness in alcohol-exposed mice. Taken together, our results suggest that EA could be used as a dietary supplement for alcoholic hepatitis patients.
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