Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Ryu, Jung-Hwa] Seoul Natl Univ Hosp, Transplantat Ctr, Seoul, South Korea; [Ryu, Jung-Hwa] Ewha Womans Univ, Nephrol, Seoul Hosp, Seoul, South Korea; [Koo, Tai Yeon] Seongnam Citizens Med Ctr, Nephrol, Seongnam, South Korea; [Ro, Han] Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; [Cho, Jang-Hee] Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; [Kim, Myung-Gyu] Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Ha Huh, Kyu] Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea; [Park, Jae Berm] Sungkyunkwan Univ, Seoul Samsung Med Ctr, Dept Surg, Seoul, South Korea; [Lee, Sik] Chonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; [Han, Seungyeup] Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Daegu, South Korea; [Kim, Jayoun] Seoul Natl Univ Hosp, Med Res Collaborating Ctr, Seoul, South Korea; [Oh, Kook-Hwan] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Yang, Jaeseok] Yonsei Univ, Dept Internal Med, Div Nephrol, Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, gold, Green Published
- 발행기관 PUBLIC LIBRARY SCIENCE
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183634
- 본문언어 영어
- Published As http://dx.doi.org/10.1371/journal.pone.0257981
- PubMed https://pubmed.ncbi.nlm.nih.gov/34606505
초록/요약
Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1-3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.</p>
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