Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets
- 주제(키워드) microstructured surfaces , respiratory droplets , nanoparticles , virus particles , fomite transmission , directional particle aggregation
- 주제(기타) Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
- 설명문(일반) [Kim, Seok; Choi, Su Hyun; Kim, Do Hyeog; Cho, Young Tae] Changwon Natl Univ, Dept Mech Engn, Chang Won 51140, South Korea; [Kim, Seok; Kim, Woo Young; Shin, Seunghang; Cho, Young Tae] Changwon Natl Univ, Dept Smart Mfg Engn, Chang Won 51140, South Korea; [Nam, Sang-Hoon; Fang, Nicholas X.] MIT, Dept Mech Engn, Cambridge, MA 02139 USA; [Lee, Heedoo; Choi, Hyeok Jae] Changwon Natl Univ, Dept Biol & Chem, Chang Won 51140, South Korea; [Lee, Eungman] Ewha Womans Univ, Coll Med, Dept Radiat Oncol, Seoul 07804, South Korea; [Park, Jung-Hyun; Jo, Inho] Ewha Womans Univ, Coll Med, Dept Mol Med, Seoul 07804, South Korea; [Jo, Inho] Ewha Womans Univ, Med Ctr, Ewha Educ & Res Ctr Infect, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183635
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acsnano.1c01636
- PubMed https://pubmed.ncbi.nlm.nih.gov/34339604
초록/요약
Evaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces. For the proof-of-concept, interconnected hexagonal and inverted pyramidal microwall were fabricated using ultravioletbased nanoimprint lithography, which is considered to be a promising scalable manufacturing process. We demonstrated the potentials of an engineered microcavity surface to limit the contact transfer of particle aggregates deposited with the evaporation of microdroplets by 93% for hexagonal microwall and by 96% for inverted pyramidal microwall. The particle capture potential of the interconnected microstructures was also investigated using biological particles, including adenoviruses and lung-derived extracellular vesicles. The findings indicate that the proposed microstructured surfaces can reduce the indirect fomite transmission of highly infectious agents, including norovirus, rotavirus, or SARS-CoV-2, via respiratory droplets.
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