Recent advances in nonalcoholic fatty liver disease metabolomics
- 주제(키워드) Lipids , Bile acids and salts , Amino acids , Fatty liver , Phenotype
- 주제(기타) Gastroenterology & Hepatology
- 설명문(일반) [Kim, Hwi Young] Ewha Womans Univ, Dept Internal Med, Coll Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN ASSOC STUDY LIVER
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183687
- 본문언어 영어
- Published As http://dx.doi.org/10.3350/cmh.2021.0127
- PubMed https://pubmed.ncbi.nlm.nih.gov/34098712
초록/요약
The clinical phenotypes of nonalcoholic fatty liver disease (NAFLD) encompass from simple steatosis to nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis or cirrhosis. Liver biopsy has been the standard to diagnose NASH. However, there has been strong need for precise and accurate noninvasive tests because of invasiveness and sampling variability of biopsy. Metabolomics has drawn attention as a promising diagnostic methodology in the field of NAFLD, particularly to unravel metabolic alterations which plays relevant roles in the progression of NASH. There have been numerous metabolomics researches to find new biomarker of NASH in the last decade, fueled by the recent advances in the metabolomics methodology. This review briefly covers recent research advances on the lipidomics, amino acids and bile acid metabolomics regarding continuing attempts to discover relevant biomarkers for NASH. (Clin Mol Hepatol 2021;27:553-559)
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