The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Jin, Sohee] Yonsei Barun Hosp, Dept Anesthesiol & Pain Med, Seoul, South Korea; [Baik, Hee Jung; Cho, Sooyoung; Chung, Rack Kyung] Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Anesthesiol & Pain Med, Seoul, South Korea; [Kong, Kyoung Ae] Ewha Womans Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Kim, Youn Jin] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Anesthesiol & Pain Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 PUBLIC LIBRARY SCIENCE
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183691
- 본문언어 영어
- Published As http://dx.doi.org/10.1371/journal.pone.0257467
- PubMed https://pubmed.ncbi.nlm.nih.gov/34520506
초록/요약
The aim of this study is to compare the effects of neuromuscular blockade (NMB) on phase lag entropy (PLE) and the bispectral index (BIS). We recorded the BIS, electromyograph (EMG) activity on a BIS monitor (EMG_BIS), PLE, and EMG activity on a PLE monitor (EMG_PLE) in 40 patients receiving general anesthesia. During the awake state, we analyzed the changes in parameters before and 2 min after the eyes were closed. During sedation, we compared the changes in the parameters before and at 4 min after injecting rocuronium (group R) or normal saline (group C) between the two groups. During anesthesia, we compared the changes in parameters before and at 4 min after injecting sugammadex (group B) or normal saline (group D) between the two groups. During the awake state, the BIS, EMG_BIS, and EMG_PLE, but not PLE, decreased significantly with closed eyes. An effect of EMG on the BIS was evident, but not on PLE. During sedation, the BIS decreased with the decrease in EMG_BIS regardless of NMB caused by rocuronium, but NMB decreased PLE, although the degree of the decrease in EMG_PLE after NMB was similar to that after placebo. To determine the effect of NMB on electroencephalograms (EEGs) in groups R and C, we plotted the power spectra before and at 4 min after injecting rocuronium or normal saline. Changes in slow and delta frequency bands were observed at 4 min after injecting rocuronium relative to before injecting rocuronium. There was no effect of EMG on either the BIS or PLE during anesthesia. In conclusion, the effect of electromyograph activity and/or neuromuscular blockade on BIS or PLE depends on the level of consciousness.
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