Medical Management of Constipation in Elderly Patients: Systematic Review
- 주제(키워드) Aged , Constipation , Laxatives , Systematic review
- 주제(기타) Gastroenterology & Hepatology; Clinical Neurology
- 설명문(일반) [Kang, Seung Joo] Seoul Natl Univ Hosp Healthcare Syst, Dept Internal Med, Gangnam Ctr, Seoul, South Korea; [Cho, Young Sin] Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Cheonan, Chungcheongnam, South Korea; [Lee, Tae Hee] Soonchunhyang Univ, Inst Digest Res, Seoul, South Korea; [Kim, Seong-Eun] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Ryu, Han Seung] Wonkwang Univ, Sch Med, Dept Internal Med, Iksan, Jeollabuk Do, South Korea; [Ryu, Han Seung] Wonkwang Univ, Sch Med, Digest Dis Res Inst, Iksan, Jeollabuk Do, South Korea; [Kim, Jung-Wook] Kyung Hee Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea; [Park, Seon-Young] Chonnam Natl Univ, Div Gastroenterol, Dept Internal Med, Sch Med, Gwangju, South Korea; [Lee, Yoo Jin] Keimyung Univ, Div Gastroenterol & Hepatol, Dept Internal Med, Sch Med, Daegu, South Korea; [Shin, Jeong Eun] Dankook Univ, Coll Med, Dept Internal Med, 201 Manghyangro, Cheonan, Chungcheongnam, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183709
- 본문언어 영어
- Published As http://dx.doi.org/10.5056/jnm20210
- PubMed https://pubmed.ncbi.nlm.nih.gov/34642269
초록/요약
Background/Aims Constipation is a common gastrointestinal problem in the elderly. Because of the limitations of life style modifications and the comorbidity, laxative use is also very common. Therefore, this study reviews the latest literature on the effect and safety of laxative in the elderly. Methods A systematic review of randomized controlled trials investigating the effectiveness and safety of laxatives for constipation in elderly patients over 65 years old were performed using the following databases: PubMed, EMBASE, and the Cochrane Library. Results Twenty-three randomized controlled trials were included in this review. Among the selected studies, 9 studies compared laxative with placebo and 5 studies compared laxatives of the same type. Four studies compared different types of laxatives or compared combination agents. Five studies compared novel medications such as prucalopride, lubiprostone, and elobixibat with placebo. Psyllium, calcium polycarbophil, lactulose syrup, lactitol, polyethylene glycol, magnesium hydroxide, stimulant laxative with or without fiber, and other medications were more effective than placebo in elderly constipation patients in short-term. Generally, the frequency and severity of adverse effects of laxative were similar between the arms of studies. Conclusions Bulk laxative, osmotic laxative, stimulant laxative with or without fiber, and other medications can be used in elderly patients in short-term within 3 months with reasonable safety. However, the quality of included studies was not high and most of studies was conducted in a small number of patients. Among these laxatives, polyethylene glycol seems to be safe and effective in long-term use of about 6 months in elderly patients.
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