Resveratrol-β-Lactoglobulin Composite Nanocoating by Layer-by-Layer Assembly with Fe(III)-Tannic Acid Complex
- 주제(키워드) Nanostructures , Resveratrol , Tannic acid , Thin films , β-Lactoglobulin
- 등재 SCIE, SCOPUS
- 발행기관 John Wiley and Sons Ltd
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183958
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/asia.202100923
- PubMed https://pubmed.ncbi.nlm.nih.gov/34581017
초록/요약
Resveratrol (3,4’,5-trihydroxystilbene) is beneficial to human health due to its diverse biological activities including its anti-inflammatory and anti-oxidative effects as confirmed by pharmacokinetic tests. Despite these clinical merits, resveratrol's limited hydrosolubility and chemical vulnerability remain challenging with regard to developing a controlled delivery system with enhanced bioavailability. In this work, we report a resveratrol-β-lactoglobulin (R-BLG) composite nanocoating through a layer-by-layer assembly with Fe(III)-tannic acid nanofilms. The R-BLG composite nanocoating can be formed in planar and particulate substrates, showing excellent film stability under a broad range of pH values and against enzymatic digestion during a weeklong incubation. We envision that the proteinaceous nanocoating herein could be combined with existing pharmaceutical carrier materials (e. g., microcapsules and nanoparticles) to realize advanced drug delivery systems with an expanded repertoire of hydrophobic drugs. © 2021 Wiley-VCH GmbH
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