Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits
- 주제(키워드) Hyperoxygenation , Chronic stress , Mitochondria , Neurogenesis
- 주제(기타) Medicine, Research & Experimental
- 주제(기타) Neurosciences
- 설명문(일반) [Choi, Juli; Kwon, Hye-Jin; Han, Pyung-Lim] Ewha Womans Univ, Dept Brain & Cognit Sci, Seoul 03760, South Korea; [Seoh, Ju-Young] Ewha Womans Univ, Coll Med, Dept Microbiol, Seoul 07985, South Korea; [Seoh, Ju-Young] GI Biome Inc, Cent Res Lab, Seongnam 13201, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190241
- 본문언어 영어
- Published As https://doi.org/10.5607/en21029
- PubMed https://pubmed.ncbi.nlm.nih.gov/34983882
초록/요약
Hyperoxygenation therapy remediates neuronal injury and improves cognitive function in various animal models. In the present study, the optimal conditions for hyperoxygenation treatment of stress-induced maladaptive changes were investigated. Mice exposed to chronic restraint stress (CRST) produce persistent adaptive changes in genomic responses and exhibit depressive-like behaviors. Hyperoxygenation treatment with 100% O-2 (HO2) at 2.0 atmospheres absolute (ATA) for 1 h daily for 14 days in CRST mice produces an antidepressive effect similar to that of the antidepressant imipramine. In contrast, HO2 treatment at 2.0 ATA for 1 h daily for shorter duration (3, 5, or 7 days), HO2 treatment at 1.5 ATA for 1 h daily for 14 days, or hyperbaric air treatment at 2.0 ATA (42% O-2) for 1 h daily for 14 days is ineffective or less effective, indicating that repeated sufficient hyperoxygenation conditions are required to reverse stress-induced maladaptive changes. HO2 treatment at 2.0 ATA for 14 days restores stress-induced reductions in levels of mitochondrial copy number, stress-induced attenuation of synaptophysin-stained density of axon terminals and MAP-2-staining dendritic processes of pyramidal neurons in the hippocampus, and stress-induced reduced hippocampal neurogenesis. These results suggest that HO2 treatment at 2.0 ATA for 14 days is effective to ameliorate stress-induced neuronal and behavioral deficits.
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