Structural Requirements of 1-(2-Pyridinyl)-5-pyrazolones for Disproportionation of Boronic Acids
- 주제(키워드) 1-(2-pyridinyl)-5-pyrazolone , [N , O]-bidentate ligand , arylboronic acid , base , diarylborination , four-coordinate boron(III) complex
- 주제(기타) Biochemistry & Molecular Biology
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Cho, Joungmo; Han, Yohan; Lee, Kee-In] Korea Res Inst Chem Technol, Daejeon 34114, South Korea; [Sadu, Venkata Subbaiah; Lee, Kee-In] Mol & Mat Co Ltd, R&D Ctr, B 219 Daeduck BIZ Ctr, Daejeon 34013, South Korea; [Bae, Yunsoo] Ewha Womans Univ, Dept Life Sci, Seoul 03760, South Korea; [Lee, Hwajeong] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190319
- 본문언어 영어
- Published As https://doi.org/10.3390/molecules26226814
- PubMed https://pubmed.ncbi.nlm.nih.gov/34833904
초록/요약
We observed an unusual formation of four-coordinate boron(III) complexes from the reaction of 1-(2-pyridinyl)-5-pyrazolone derivatives with arylboronic acids in the basic media. The exact mechanism is not clear; however, the use of unprotected boronic acid and the presence of a bidentate ligand appeared to be the key structural requirements for the transformation. The results suggest that base-promoted disproportionation of arylboronic acid with the assistance of the [N,O]-bidentate ligation of 1-(2-pyridinyl)-5-pyrazolone should take place and facilitate the formation of pyrazole diarylborinate. Experiments to obtain a deeper understanding of its mechanism are currently underway.
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