Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome
- 주제(키워드) Oral immunotherapy , Nanomedicine , Mucosal Immunity , Peyer's patches , Lamina propria , Intestinal barrier , Gut microbiota
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Lee, Yonghyun] Ewha Womans Univ, Dept Pharm, Coll Pharm, Seoul 03760, South Korea; [Lee, Yonghyun] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Kamada, Nobuhiko] Univ Michigan, Div Gastroenterol, Dept Internal Med, Med Ctr Dr, Ann Arbor, MI 48109 USA; [Moon, James J.] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA; [Moon, James J.] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA; [Moon, James J.] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190426
- 본문언어 영어
- Published As https://doi.org/10.1016/j.addr.2021.114021
- PubMed https://pubmed.ncbi.nlm.nih.gov/34710529
초록/요약
The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various systemic diseases. Factors that can affect the health and disease of both GIT and the human body include 1) the mucosal immune system composed of the gut-associated lymphoid tissues and the lamina propria, 2) the intestinal barrier composed of mucus and intestinal epithelium, and 3) the gut microbiota. Selective delivery of drugs, including antigens, immune-modulators, intestinal barrier enhancers, and gutmicrobiome manipulators, has shown promising results for oral vaccines, immune tolerance, treatment of inflammatory bowel diseases, and other systemic diseases, including cancer. However, physicochemical and biological barriers of the GIT present significant challenges for successful translation. With the advances of novel nanomaterials, oral nanomedicine has emerged as an attractive option to not only overcome these barriers but also to selectively deliver drugs to the target sites in GIT. In this review, we discuss the GIT factors and physicochemical and biological barriers in the GIT. Furthermore, we present the recent progress of oral nanomedicine for oral vaccines, immune tolerance, and anti inflammation therapies. We also discuss recent advances in oral nanomedicine designed to fortify the intestinal barrier functions and modulate the gut microbiota and microbial metabolites. Finally, we opine about the future directions of oral nano-immunotherapy. (c) 2021 Elsevier B.V. All rights reserved.
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