Association between SLCO1B1 polymorphism and methotrexate-induced hepatotoxicity: a systematic review and meta-analysis
- 주제(키워드) hepatotoxicity , malignancies , methotrexate , T521C polymorphism
- 주제(기타) Oncology
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Han, Ji Min] Chungbuk Natl Univ, Coll Pharm, Cheongju, Chungcheongbuk, South Korea; [Choi, Kyung Hee] Sunchon Natl Univ, Coll Pharm, Sunchon, Jeollanam Do, South Korea; [Lee, Hong Hyun; Gwak, Hye Sun] Ewha Womans Univ, Grad Sch Clin Biohlth, Seoul 03760, South Korea; [Gwak, Hye Sun] Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Gwak, Hye Sun] Ewha Womans Univ, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 LIPPINCOTT WILLIAMS & WILKINS
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190445
- 본문언어 영어
- Published As https://doi.org/10.1097/CAD.0000000000001125
- PubMed https://pubmed.ncbi.nlm.nih.gov/34726639
초록/요약
Reports on the association between the solute carrier organic anion transporter 1B1 (SLCO1B1) T521C polymorphism and methotrexate-induced hepatotoxicity in patients with malignancies are inconsistent. This meta-analysis evaluated the association between the SLCO1B1 T521C polymorphism and methotrexate-induced hepatotoxicity. We performed a systematic review of previous reports from the PubMed, Web of Science, and EMBASE databases, and a meta-analysis was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the effect of the SLCO1B1 T521C polymorphism on the occurrence of methotrexate-induced hepatotoxicity. In total, data from five studies including 465 patients were analyzed. Patients had received a high-dose methotrexate regimen (1-5 g/m(2)). The SLCO1B1 variant allele (C allele) carriers had a 1.9-fold higher risk of hepatotoxicity than wild-type homozygote carriers (TT; OR, 1.94; 95% CI, 1.14-3.31). This meta-analysis demonstrated that C allele carriers of the SLCO1B1 polymorphism had a higher risk of hepatotoxicity than patients with the TT genotype. The SLCO1B1 T521C polymorphism may be a useful predictor for methotrexate-induced hepatotoxicity in patients with malignancies.
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