Effects of host and pathogenicity on mutation rates in avian influenza A viruses
- 주제(키워드) avian influenza , mutation rate , host specificity , pathogenicity , neutral substitution
- 주제(기타) Virology
- 설명문(일반) [Kim, Gwanghun; Shin, Hyun Mu; Kim, Hang-Rae] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul 03080, South Korea; [Shin, Hyun Mu; Kim, Hang-Rae] Seoul Natl Univ, Coll Med, BK21 Four Biomed Sci Project, Seoul 03080, South Korea; [Shin, Hyun Mu; Kim, Hang-Rae] Seoul Natl Univ, Coll Med, Med Res Inst, Seoul 03080, South Korea; [Shin, Hyun Mu; Kim, Hang-Rae] Seoul Natl Univ, Wide River Inst Immunol, Hongcheon 25159, South Korea; [Kim, Hang-Rae] Seoul Natl Univ, Coll Med, Dept Anat & Cell Biol, Seoul 03080, South Korea; [Kim, Yuseob] Ewha Womans Univ, Div EcoSci, Seoul 03760, South Korea; [Kim, Yuseob] Ewha Womans Univ, Dept Life Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 OXFORD UNIV PRESS
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190527
- 본문언어 영어
- Published As https://doi.org/10.1093/ve/veac013
- PubMed https://pubmed.ncbi.nlm.nih.gov/35295747
초록/요약
Mutation is the primary determinant of genetic diversity in influenza viruses. The rate of mutation, measured in an absolute time-scale, is likely to be dependent on the rate of errors in copying RNA sequences per replication and the number of replications per unit time. Conditions for viral replication are probably different among host taxa, potentially generating the host specificity of the viral mutation rate, and possibly between highly and low pathogenic (HP and LP) viruses. This study investigated whether mutation rates per year in avian influenza A viruses depend on host taxa and pathogenicity. We inferred mutation rates from the rates of synonymous substitutions, which are assumed to be neutral and thus equal to mutation rates, at four segments that code internal viral proteins (PB2, PB1, PA, NP). On the phylogeny of all avian viral sequences for each segment, multiple distinct subtrees (clades) were identified that represent viral subpopulations, which are likely to have evolved within particular host taxa. Using simple regression analysis, we found that mutation rates were significantly higher in viruses infecting chickens than domestic ducks and in those infecting wild shorebirds than wild ducks. Host dependency of the substitution rate was also confirmed by Bayesian phylogenetic analysis. However, we did not find evidence that the mutation rate is higher in HP than in LP viruses. We discuss these results considering viral replication rate as the major determinant of mutation rate per unit time.
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