Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
- 주제(키워드) REM sleep behavior disorder (RBD) , sleep , autonomic dysfunction , I-123-metaiodobenzylguanidine (MIBG) scintigraphy , REM sleep without atonia
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [You, Sooyeoun; Kim, Keun Tae; Cho, Yong Won] Keimyung Univ, Sch Med, Dept Neurol, Daegu 42601, South Korea; [Won, Kyoung Sook] Keimyung Univ, Sch Med, Dept Nucl Med, Daegu 42601, South Korea; [Lee, Hyang Woon] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul 07985, South Korea; [Lee, Hyang Woon] Ewha Womans Univ, Sch Med, Dept Med Sci, Seoul 07985, South Korea; [Lee, Hyang Woon] Ewha Womans Univ, Sch Med, Dept Computat Med, Seoul 07985, South Korea; [Lee, Hyang Woon] Ewha Womans Univ, Sch Med, Dept Syst Hlth Sci & Engn, Seoul 07985, South Korea; [Lee, Hyang Woon] Ewha Med Res Inst, Seoul 07985, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190767
- 본문언어 영어
- Published As https://doi.org/10.3390/jcm10225414
- PubMed https://pubmed.ncbi.nlm.nih.gov/34830696
초록/요약
I-123-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was performed to assess cardiac autonomic dysfunction and demonstrate its correlation with clinical and polysomnographic characteristics in patients with isolated rapid eye movement (REM) sleep behavior disorder. All subjects including 39 patients with isolated REM sleep behavior disorder and 17 healthy controls underwent MIBG cardiac scintigraphy for cardiac autonomic dysfunction assessment. The isolated REM sleep behavior disorder was confirmed by in-lab overnight polysomnography. A receiver operating curve was constructed to determine the cut-off value of the early and delayed heart-to-mediastinum ratio in patients with isolated REM sleep behavior disorder. Based on each cut-off value, a comparison analysis of REM sleep without atonia was performed by dividing isolated REM sleep behavior disorder patients into two groups. MIBG uptake below the cut-off value was associated with higher REM sleep without atonia. The lower heart-to-mediastinum ratio had significantly higher REM sleep without atonia (%), both with cut-off values of early (11.0 & PLUSMN; 5.6 vs. 29.3 & PLUSMN; 23.2%, p = 0.018) and delayed heart-to-mediastinum ratio (9.1 & PLUSMN; 4.3 vs. 30.0 & PLUSMN; 22.9%, p = 0.011). These findings indicate that reduced MIBG uptake is associated with higher REM sleep without atonia in isolated REM sleep behavior disorder.
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