Necessity for immediate referral to colposcopy according to human papillomavirus (HPV) genotypes in negative-cytology women
- 주제(키워드) Uterine cervical neoplasms , Human papillomavirus , Colposcopy , Cytology
- 주제(기타) Oncology
- 주제(기타) Obstetrics & Gynecology
- 설명문(일반) [Song, Taejong] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Obstet & Gynecol, Sch Med, Seoul 03181, South Korea; [Seong, Seok Ju] CHA Univ, CHA Gangnam Med Ctr, Dept Obstet & Gynecol, Seoul 06135, South Korea; [Lee, Seon-Kyung] CHA Univ, Dept Obstet & Gynecol, CHA Ilsan Med Ctr, Goyang 10414, South Korea; [Kim, Byoung-Ryun] Wonkwang Univ, Sch Med, Dept Obstet & Gynecol, Iksan 54538, South Korea; [Ju, Woong] Ewha Womans Univ, Dept Obstet & Gynecol, Sch Med, Seoul 07985, South Korea; [Kim, Ki Hyung] Pusan Natl Univ, Dept Obstet & Gynecol, Sch Med, Busan 49241, South Korea; [Nam, Kyehyun] Soonchunhyang Univ, Dept Obstet & Gynecol, Bucheon Hosp, Bucheon 14584, South Korea; [Sim, Jae Chul] Dongguk Univ, Grad Sch Med, Gyeongju Hosp, Dept Obstet & Gynecol, Gyeongju 38067, South Korea; [Kim, Tae Jin] Konkuk Univ, Dept Obstet & Gynecol, Sch Med, Seoul 05030, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold
- 발행기관 IMR PRESS
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190779
- 본문언어 영어
- Published As https://doi.org/10.31083/j.ejgo4206170
초록/요약
Objective: This study aimed to investigate the risk of cervical intraep-ithelial neoplasia grade 2 or worse (CIN2+) according to high-risk (HR) human papillomavirus (HPV) genotypes in women with nega-tive cytology. Methods: A total of 33,531 Korean women who received Pap cytology + HPV co-testing for cervical cancer screening were ret-rospectively collected. To evaluate the risk of CIN2+ according to HR-HPV genotypes, odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by a logistic regression model. Results: Of 1337 women with negative Pap result but HR-HPV positive included in the analysis, 160 (12.0%) women were infected by HPV16 or HPV18, while 1177 (88.0%) women were had other HR-HPVs infections. The preva-lence of CIN2+ diseases was 3.7% (50 of 1337). In women with HPV16-negative, HPV18-negative, but other HR-HPV-positive (n =1177), the risk for CIN2+ lesion was significantly increased in women with mul-tiple HR-HPV infections (OR, 5.40; 95% CI, 2.37-12.73), those with HPV58 (OR, 4.83; 95% CI, 2.17-10.74), and those with HPV35 (OR, 4.77; 95% CI, 1.36-16.77). Conclusion: Colposcopy should also be referred to women with multiple HR-HPVs, HPV35, or HPV58 infections, as well as those with HPV16 and HPV18.
more