Correlation between Gut Microbiota and Six Facets of Neuroticism in Korean Adults
- 주제(키워드) microbiota , neuroticism , gut-brain axis , 16s sequencing , anxiety , depression , vulnerability
- 주제(기타) Health Care Sciences & Services
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Park, Eunkyo; Kim, Hyung-Lae; Jung, Sung-Chul] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul 07804, South Korea; [Yun, Kyung Eun; Kim, Mi-Hyun; Kim, Jimin; Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Ctr Cohort Studies,Total Healthcare Ctr, Seoul 04514, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Seoul 03181, South Korea; [Chang, Yoosoo; Ryu, Seungho; Kim, Han-Na] Sungkyunkwan Univ, SAIHST, Dept Clin Res Design & Evaluat, Seoul 06355, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Med Res Inst, Seoul 03181, South Korea; [Jung, Sung-Chul] Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190786
- 본문언어 영어
- Published As https://doi.org/10.3390/jpm11121246
- PubMed https://pubmed.ncbi.nlm.nih.gov/34945718
초록/요약
A person high in neuroticism is more likely to experience anxiety, stress, worry, fear, anger, and depression. Previous studies have shown that the gut microbiota can influence personality and mental disorders, including stress, anxiety, and depression, through the gut-brain axis. Here, we investigated the correlations between the sub-facet of neuroticism and gut microbiota using the Revised NEO Personality Inventory and the 16S rRNA gene sequencing data 784 adults. We found that the high anxiety and vulnerability group showed significantly lower richness in microbial diversity than a group with low anxiety and vulnerability. In beta diversity, there was a significant difference between the low and high groups of anxiety, self-consciousness, impulsiveness, and vulnerability. In taxonomic compositions, Haemophilus belonging to Gammaproteobacteria was correlated with the Neuroticism domain as well as N1 anxiety and N6 vulnerability facets. The high N1 anxiety and N6 vulnerability group was correlated with a low abundance of Christensenellaceae belonging to Firmicutes Clostridia. High N4 self-consciousness was correlated with a low abundance of Alistipes and Sudoligranulum. N5 impulsiveness was correlated with a low abundance of Oscillospirales. Our findings will contribute to uncovering the potential link between the gut microbiota and neuroticism, and the elucidation of the correlations of the microbiome-gut-brain axis with behavioral changes and psychiatric cases in the general population.
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