Gut Microbiota Composition across Normal Range Prostate-Specific Antigen Levels
- 주제(키워드) prostate-specific antigen , androgen receptor activity , gut microbiota , 16S rRNA
- 주제(기타) Health Care Sciences & Services
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Med Res Inst, Seoul 03181, South Korea; [Kim, Han-Na; Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, SAIHST, Dept Clin Res Design & Evaluat, Seoul 06355, South Korea; [Kim, Jae-Heon; Yang, Dongmin] Soonchunhyang Univ, Seoul Hosp, Med Coll, Dept Urol, Seoul 04401, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Sch Med,Ctr Cohort Studies, Seoul 04514, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Occupat & Environm Med, Seoul 03181, South Korea; [Kim, Hyung-Lae] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190788
- 본문언어 영어
- Published As https://doi.org/10.3390/jpm11121381
- PubMed https://pubmed.ncbi.nlm.nih.gov/34945854
초록/요약
Animal studies have shown the interaction between androgens and the gut microbiome directly and indirectly; however, limited evidence from human studies is available. To evaluate the association between prostate-specific antigen (PSA) levels within the normal range, reflective of androgen receptor activity, and the gut microbiota composition, a cross-sectional analysis was performed in 759 Korean men aged between 25 and 78 years with normal PSA levels of <= 4.0 ng/mL. We evaluated the biodiversity of gut microbiota as well as the taxonomic and functional signatures associated with PSA levels using 16S rRNA gene sequencing data. PSA levels within the normal range were categorized into three groups: lowest quartile (G1), interquartile range (G2, reference), and highest quartile (G3). The G3 group had higher microbial richness than the G2 group, although it was dominated by a few bacteria. An increase in Escherichia/Shigella abundance and a reduction in Megamonas abundance in the G3 group were also detected. A U-shaped relationship was observed between the three groups across most analyses, including biodiversity, taxonomic composition, and inferred pathways in the gut microbiota. This study showed different microbiota patterns across PSA levels within the normal range. Further studies are required to elucidate the role of microbiota in regulating PSA levels.
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