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Development and Validity Assessment of a Self-evaluation Questionnaire for Functional Dyspepsia: A Multicenter Prospective Study in Korea

  • 주제(키워드) Dyspepsia , Patient outcome assessment , Surveys and questionnaires , Validation study
  • 주제(기타) Gastroenterology & Hepatology
  • 주제(기타) Clinical Neurology
  • 설명문(일반) [Jung, Kyoungwon] Kosin Univ, Dept Internal Med, Coll Med, Busan, South Korea; [Jung, Hye-Kyung; Tae, Chung Hyun] Ewha Womans Univ, Coll Med, Seoul, South Korea; [Kwon, Joong Goo] Daegu Catholic Univ, Sch Med, Daegu, South Korea; [Bang, Ki Bae] Dankook Univ, Coll Med, Cheonan, Chungcheongnam, South Korea; [Park, Jong Kyu] Univ Ulsan, Gangneung Asan Hosp, Coll Med, Kangnung, Gangwon Do, South Korea; [Lee, Ju Yup] Keimyung Univ, Sch Med, Daegu, South Korea; [Shin, Cheol Min] Seoul Natl Univ, Bundang LlospitaI, Seongnani, Gyeonggi Do, South Korea; [Oh, Jung Hwan; Choi, Myung-Gyu] Catholic Univ Korea, Coll Med, Seoul, South Korea; [Song, Kyung Ho] CHA Univ, Ilsan Med Ctr, Ilsan, Gyeonggi Do, South Korea; [Lee, Oh Young] Hanyang Univ, Coll Med, Seoul, South Korea
  • 등재 SCIE, SCOPUS, KCI등재
  • OA유형 gold, Green Published
  • 발행기관 KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
  • 발행년도 2022
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000190808
  • 본문언어 영어
  • Published As https://doi.org/10.5056/jnm20250
  • PubMed https://pubmed.ncbi.nlm.nih.gov/34980694

초록/요약

Background/Aims Patient-reported outcomes (PROs) are essential for clinical decision making, conduction of clinical research, and drug application acquisition in functional gastrointestinal disorders. The aim of this study is to develop a PRO instrument and to determine the respondents' perception of the efficacy of therapeutic agents for functional dyspepsia (FD). Methods A self-evaluation questionnaire for dyspepsia (SEQ-DYSPEPSIA) was developed and validated through a structured process. The 2-week reproducibility was evaluated, and the construct validity was assessed by correlating the scores of SEQ-DYSPEPSIA (including typical and major FD symptom subscales). Finally, the response to medication was assessed by comparing the changes after 4 weeks of treatment. Results A total of 193 Korean patients (age 48.5 +/- 13.6 years, 69.4% women) completed the questionnaire. SEQ-DYSPEPSIA with 11 items had a good internal consistency (alpha = 0.770-0.905) and an acceptable test-retest reliability (intraclass correlation coefficient = 0.733-0.859). The self-evaluation questionnaire (SEQ)-major FD score highly correlated with the postprandial fullness/early satiety domain of the Patient Assessment of Gastrointestinal Symptom Severity Index (correlation coefficient r = 0.741, P < 0.001), Nepean Dyspepsia Index-Korean version (NDI-K) (r = 0.839, P < 0.001), and NDI-K quality of life (r = -0.275 to -0.344, P < 0.001). After medical treatment, decrease in the SEQ-typical FD and SEQ-major FD was significantly greater in the responder group than in non responder group (P = 0.019 and P = 0.009, respectively). Conclusion This study suggests that the Korean version of SEQ-DYSPEPSIA has good reliability and validity, and can be a useful PRO measurement tool in patients with FD. (J Neurogastroenterol Motil 2022;28:111-120)

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