Potential application of biomimetic exosomes in cardiovascular disease: focused on ischemic heart disease
- 주제(키워드) Biomimetics , Cardiovascular disease , Exosome , Extracellular vesicles , Regenerative medicine
- 주제(기타) Biochemistry & Molecular Biology
- 설명문(일반) [Kang, In Sook; Kwon, Kihwan] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190818
- 본문언어 영어
- Published As https://doi.org/10.5483/BMBRep.2022.55.1.161
- PubMed https://pubmed.ncbi.nlm.nih.gov/34903320
초록/요약
Cardiovascular disease, especially ischemic heart disease, is a major cause of mortality worldwide. Cardiac repair is one of the most promising strategies to address advanced cardiovascular diseases. Despite moderate improvement in heart function via stem cell therapy, there is no evidence of significant improve-ment in mortality and morbidity beyond standard therapy. The most salutary effect of stem cell therapy are attributed to the paracrine effects and the stem cell-derived exosomes are known as a major contributor. Hence, exosomes are emerging as a pro-mising therapeutic agent and potent biomarkers of cardiovas-cular disease. Furthermore, they play a role as cellular cargo and facilitate intercellular communication. However, the clinical use of exosomes is hindered by the absence of a standard ope-rating procedures for exosome isolation and characterization, problems related to yield, and heterogeneity. In addition, the successful clinical application of exosomes requires strategies to optimize cargo, improve targeted delivery, and reduce the elimination of exosomes. In this review, we discuss the basic concept of exosomes and stem cell-derived exosomes in cardio-vascular disease, and introduce current efforts to overcome the limitations and maximize the benefit of exosomes including engineered biomimetic exosomes.
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