Nationwide Survey for Current Status of Laboratory Diagnosis of Clostridioides difficile Infection in Korea
- 주제(키워드) Clostridioides difficile Infection , Laboratory Diagnosis , Toxin AB Enzyme Immunoassay , Nucleic Acid Amplification Test , Culture , Glutamate Dehydrogenase , Survey
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Chung, Hae-Sun] Ewha Womans Univ, Dept Lab Med, Coll Med, Seoul, South Korea; [Park, Jeong Su] Seoul Natl Univ, Dept Lab Med, Bundang Hosp, Seongnam, South Korea; [Shin, Bo-Moon] Inje Univ, Sanggye Paik Hosp, Sch Med, Dept Lab Med, 1342 Dongil Ro, Seoul 01757, South Korea; [Yoo, Hyeon Mi] Inje Univ, Sanggye Paik Hosp, Infect Control Off, Seoul, South Korea; [Kim, Heejung] Yonsei Univ, Yongin Severance Hosp, Dept Lab Med, Coll Med, Yongin, South Korea; [Cho, Jihyun] Wonkwang Univ Hosp, Dept Lab Med, Iksan, South Korea; [Lee, Chae Hoon] Yeungnam Univ, Coll Med, Dept Lab Med, Daegu, South Korea; [Ryoo, Nam Hee] Keimyung Univ, Dept Lab Med, Sch Med, Daegu, South Korea; [Kim, Jae-Seok] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Lab Med, Coll Med, Seoul, South Korea; [Chung, Jae-Woo] Dongguk Univ, Dept Lab Med, Ilsan Hosp, Goyang, South Korea; [Hong, Ki Ho] Yonsei Univ, Severance Hosp, Dept Lab Med, Coll Med, Seoul, South Korea; [Kim, You Sun] Inje Univ, Seoul Paik Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Cho, Young-Seok] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul St Marys Hosp, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN ACAD MEDICAL SCIENCES
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190864
- 본문언어 영어
- Published As https://doi.org/10.3346/jkms.2022.37.e38
- PubMed https://pubmed.ncbi.nlm.nih.gov/35132844
초록/요약
Background: The interest in Clostridioides (Wile infection (CDI) has increased, and the choice of assays became wider since the first national survey in Korea on CDI diagnosis in 2015. We conducted a survey of the domestic CDI assays with more varied questions to understand the current situation in Korea. Methods: In April 2018, about 50 questions on the current status of CDI assays and details on implementation and perceptions were written, and a survey questionnaire was administered to laboratory medicine specialists in 200 institutions. Results: One-hundred and fifty institutions responded to the questionnaire, of which 90 (60.0%) including one commercial laboratory, performed CDI assays. The toxin AB enzyme immunoassay (toxin AR EIA), nucleic acid amplification test (NAAT), and C. difficile culture, glutamate dehydrogenase assay, alone or in combination with other assays, were used in 75 (84.3%), 52 (58.4%), 35 (36.0%), and 23 (25.8%), respectively, and 65 (73.0%) institutions performed a combination of two or more assays. The sensitivity of toxin AB EIA was more negatively perceived, and that on specificity was more positively perceived. The perception of sensitivity and specificity of NAAT was mostly positive. Perception on the algorithm test projected it as useful but in need of countermeasures. Sixty-three (73.3%) institutions responded that they performed surveillance on CDI. Conclusion: This study provides useful evidence on the current status of CDI laboratory diagnosis in Korea as well as on items that require improvement and is thought to aid in standardizing and improving the CDI laboratory diagnosis in Korea.
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