Distinctive Temporal Trajectories of Alzheimer's Disease Biomarkers According to Sex and APOE Genotype: Importance of Striatal Amyloid
- 주제(키워드) Alzheimer's disease , trajectory curve , sex , apolipoprotein E , positron emission tomography
- 주제(기타) Geriatrics & Gerontology
- 주제(기타) Neurosciences
- 설명문(일반) [Kim, Jun Pyo; Chun, Min Young; Kim, Soo-Jong; Jang, Hyemin; Kim, Hee Jin; Na, Duk L.; Seo, Sang Won] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea; [Kim, Jun Pyo] Indiana Univ Sch Med, Ctr Neuroimaging Radiol & Imaging Sci, Indianapolis, IN 46202 USA; [Kim, Soo-Jong; Kim, Hee Jin; Na, Duk L.; Seo, Sang Won] Sungkyunkwan Univ, SAIHST, Dept Hlth Sci & Technol, Seoul, South Korea; [Kim, Soo-Jong; Seo, Sang Won] Sungkyunkwan Univ, Dept Intelligent Precis Healthcare Convergence, Suwon, South Korea; [Jang, Hyemin; Kim, Hee Jin; Na, Duk L.; Seo, Sang Won] Samsung Med Ctr, Alzheimers Dis Convergence Res Ctr, Seoul, South Korea; [Kim, Hee Jin; Seo, Sang Won] Sungkyunkwan Univ, SAIHST, Dept Digital Hlth, Seoul, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Coll Med, Seoul Hosp, Dept Neurol, Seoul, South Korea; [Na, Duk L.] Samsung Med Ctr, Stem Cell & Regenerat Med Inst, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190869
- 본문언어 영어
- Published As https://doi.org/10.3389/fnagi.2022.829202
- PubMed https://pubmed.ncbi.nlm.nih.gov/35197846
초록/요약
PurposePreviously, sex and apolipoprotein E (APOE) genotype had distinct effects on the cognitive trajectory across the Alzheimer's disease (AD) continuum. We therefore aimed to investigate whether these trajectory curves including beta-amyloid (A beta) accumulation in the cortex and striatum, and tau accumulation would differ according to sex and APOE genotype. MethodsWe obtained 534 subjects for F-18-florbetapir (AV45) PET analysis and 163 subjects for F-18-flortaucipir (AV1451) PET analysis from the Alzheimer's Disease Neuroimaging Initiative database. For cortical A beta, striatal A beta, and tau SUVR, we fitted penalized splines to model the slopes of SUVR value as a non-linear function of baseline SUVR value. By integrating the fitted splines, we obtained the predicted SUVR curves as a function of time. ResultsThe time from initial SUVR to the cutoff values were 14.9 years for cortical A beta, 18.2 years for striatal A beta, and 22.7 years for tau. Although there was no difference in cortical A beta accumulation rate between women and men, striatal A beta accumulation was found to be faster in women than in men, and this temporal difference according to sex was more pronounced in tau accumulation. However, APOE epsilon 4 carriers showed faster progression than non-carriers regardless of kinds of AD biomarkers' trajectories. ConclusionOur temporal trajectory models illustrate that there is a distinct progression pattern of AD biomarkers depending on sex and APOE genotype. In this regard, our models will be able to contribute to designing personalized treatment and prevention strategies for AD in clinical practice.
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