Association between sleep parameters and longitudinal smartening of telomere length
- 주제(키워드) sleep quality , telomere length , amyloid pathology , aging , sleep duration
- 주제(기타) Cell Biology
- 주제(기타) Geriatrics & Gerontology
- 설명문(일반) [Jin, Jeong-Hwa; Kwon, Hyuk Sung; Koh, Seong-Ho; Lee, Eun-Hye; Park, Hyun-Hee; Ha, Jungsoon] Hanyang Univ, Dept Neurol, Coll Med, Guri, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Dept Neurol, Sch Med, Seoul, South Korea; [Jang, Jae-Won] Kangwon Natl Univ, Dept Neurol, Sch Med, Chunchon, South Korea; [Park, Kyung Won] Dong A Univ, Coll Med, Dept Neurol, Dong A Med Ctr, Busan, South Korea; [Kim, Eun-Joo] Pusan Natl Univ, Dept Neurol, Pusan Natl Univ Hosp, Sch Med, Busan, South Korea; [Kim, Eun-Joo] Med Res Inst, Busan, South Korea; [Kim, Hee Jin] Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul, South Korea; [Hong, Jin Yong] Yonsei Univ, Dept Neurol, Wonju Coll Med, Wonju, South Korea; [Yoon, Soo Jin] Eulji Univ, Sch Med, Dept Neurol, Eulji Univ Hosp, Daejeon, South Korea; [Yoon, Bora] Konyang Univ, Dept Neurol, Coll Med, Daejeon, South Korea; [Ha, Jungsoon] GemVax & Kael Co Ltd, Seongnam, South Korea; [Park, Jong Eun] Hanyang Univ, Coll Med, Dept Lab Med, Guri Hosp, Guri, South Korea; [Han, Myung Hoon] Hanyang Univ, Coll Med, Dept Neurosurg, Guri Hosp, Guri, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 IMPACT JOURNALS LLC
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190893
- 본문언어 영어
- PubMed https://pubmed.ncbi.nlm.nih.gov/35366243
초록/요약
Background: The relationship between sleep parameters and longitudinal shortening of telomere length is unclear. This study aimed to investigate the relationship between sleep parameters and the shortening of leukocyte telomere length (LTL) over a year. Methods: Among the participants in the validation cohort of the Korea Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease, participants who measured both baseline and follow-up (two years later) of LTL were analyzed. They were dichotomized according to the degree of LTL attrition over two years. Clinical characteristics were compared between the faster and slower LTL shortening groups (cut-off points: -0.710 kbp, n = 119 each). Multivariable logistic regression analyses were performed to determine independent relationships between faster shortening of LTL length and sleep parameters. Results: A total of 238 participants, aged 55-88 years, were included. Participants with faster LTL shortening had a shorter duration of sleep (P = 0.013) and longer sleep latency (P = 0.007). Among the components of the PSQI, subjective measures of sleep quality, sleep latency, sleep duration, and sleep efficiency were significantly worse in participants with faster LTL shortening. Multivariate logistic regression analysis showed that sleep duration (per hour, OR = 0.831, 95% CI = 0.698-0.989), sleep latency (per minute, OR = 1.013, 95% CI = 1.002-1.024), global PSQI score (OR = 1.134, 95% CI = 1.040-1.236), shortest sleep duration (OR = 5.173, 95% CI = 1.563-17.126), and lowest sleep efficiency (OR = 7.351, 95% CI = 1.943-27.946) were independently associated with faster LTL shortening. Conclusions: Poor sleep quality, specifically short sleep duration, long sleep latency, and low sleep efficiency were associated with faster longitudinal shortening of LTL.
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