Different clinical characteristics and impact of carbapenem-resistance on outcomes between Acinetobacter baumannii and Pseudomonas aeruginosa bacteraemia: a prospective observational study
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Lee, Chan Mi; Kim, Eu Suk; Song, Kyoung-Ho; Bin Kim, Hong] Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; [Kim, Young-Jun] Wonkwang Univ Hosp, Dept Internal Med, Iksan, South Korea; [Jung, Sook-In; Kim, Seong Eun; Park, Kyung-Hwa] Chonnam Natl Univ, Dept Infect Dis, Med Sch, Gwangju, South Korea; [Park, Wan Beom; Choe, Pyoeng Gyun] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Chung-Jong; Choi, Hee Jung] Ewha Womans Univ Hosp, Dept Internal Med, Seoul, South Korea; [Lee, Shinwon; Lee, Sun Hee] Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea; [Jung, Younghee] Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; [Bang, Ji Hwan] Seoul Metropolitan Boramae Hosp, Dept Internal Med, Seoul, South Korea; [Cheon, Shinhye] Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; [Kwak, Yee Gyung] Inje Univ, Dept Internal Med, Ilsan Paik Hosp, Goyang, South Korea; [Kang, Yu Min] Kangwon Natl Univ Hosp, Dept Internal Med, Chunchon, South Korea; [Kang, Yu Min] Myongji Hosp, Dept Internal Med, Goyang, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 NATURE PORTFOLIO
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190898
- 본문언어 영어
- Published As https://doi.org/10.1038/s41598-022-12482-0
- PubMed https://pubmed.ncbi.nlm.nih.gov/35595789
초록/요약
This study aimed to evaluate the differences in clinical characteristics and impact of carbapenem resistance (CR) on outcomes between Acinetobacter baumannii (Ab) and Pseudomonas aeruginosa (Pa) bacteraemia. We prospectively identified all patients with Ab and Pa bacteraemia in 10 hospitals over 1 year. Treatment failure was defined as all-cause 30-day mortality, persistent bacteraemia, or recurrent bacteraemia within 30 days. We included 304 Ab and 241 Pa bacteraemia cases. CR was detected in 216 patients (71%) with Ab bacteraemia and 55 patients (23%) with Pa bacteraemia. Treatment failure was significantly higher in CR-Ab than in CR-Pa (60.6% vs. 34.5%, P =0.001). In Ab, severe sepsis or septic shock and high Pitt bacteraemia score were independent risk factors for treatment failure in the inappropriate empirical antibiotics group. In Pa, hospital-acquired infection and high Pitt bacteraemia score were independent risk factors for treatment failure in both groups. CR was an independent risk factor in Ab for treatment failure in both groups, but not in Pa bacteraemia. We demonstrated significant differences in clinical characteristics and impact of CR on clinical
more