Role of Adjuvant Treatment in High-risk Patients Following Resection for Gallbladder Cancer
- 주제(키워드) adjuvant chemotherapy , adjuvant radiotherapy , adjuvant treatment , Gallbladder cancer , prognostic factor
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 International Institute of Anticancer Research
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190934
- 본문언어 영어
- Published As https://doi.org/10.21873/INVIVO.12787
- PubMed https://pubmed.ncbi.nlm.nih.gov/35241556
초록/요약
Aim: To identify prognostic factors for surgically resected gallbladder cancer (GBC). Patients and Methods: Medical records of 66 patients with GBC undergoing potentially curative resection between 2001 and 2017 were retrospectively reviewed. Results: After a median follow-up of 39.9 months (range=0.5-216.4 months), 22 locoregional recurrences and 25 distant metastases occurred. Adjuvant radiotherapy and adjuvant chemotherapy failed to prove efficacy in all patient groups. In patients with stage III-IV GBC, adjuvant chemotherapy showed a marginally positive effect on locoregional control (p=0.064), and was significantly beneficial for overall survival (p=0.040), and adjuvant treatment improved both locoregional control and overall survival (p=0.029 and p=0.005, respectively). On multivariate analysis, a negative resection margin was a significant prognostic factor for superior local control, and disease-free and overall survival (p=0.003, p=0.010 and p=0.005, respectively) and adjuvant treatment was associated with improved overall survival (p=0.018). Conclusion: Adjuvant treatment is recommended for patients with stage III-IV GBC following curative surgical resection. © 2022 International Institute of Anticancer Research. All rights reserved.
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