Oyster-Derived Tyr-Ala (YA) Peptide Prevents Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure by Suppressing Inflammatory, Apoptotic, Ferroptotic, and Pyroptotic Signals
- 주제(키워드) acute liver injury , apoptosis , ferroptosis , inflammation , oyster , peptide , pyroptosis
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Siregar, Adrian S.; Nyiramana, Marie Merci; Kim, Eun-Jin; Woo, Min Seok; Lee, Dong Kun; Hong, Seong-Geun; Han, Jaehee; Kang, Dawon] Gyeongsang Natl Univ, Coll Med, Dept Physiol, Jinju 52727, South Korea; [Siregar, Adrian S.; Nyiramana, Marie Merci; Kim, Eun-Jin; Woo, Min Seok; Lee, Dong Kun; Hong, Seong-Geun; Han, Jaehee; Kang, Dawon] Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Jinju 52727, South Korea; [Siregar, Adrian S.; Nyiramana, Marie Merci; Woo, Min Seok; Lee, Dong Kun; Kang, Sang Soo; Kim, Deok Ryong; Kang, Dawon] Gyeongsang Natl Univ, Dept Convergence Med Sci, Jinju 52727, South Korea; [Cho, Soo Buem] Ewha Womans Univ, Seoul Hosp, Dept Radiol, Seoul 07804, South Korea; [Kang, Sang Soo] Gyeongsang Natl Univ, Coll Med, Dept Anat, Jinju 52727, South Korea; [Kang, Sang Soo] Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Jinju 52727, South Korea; [Kim, Deok Ryong] Gyeongsang Natl Univ, Dept Biochem, Coll Med, Jinju 52727, South Korea; [Choi, Yeung Joon] Jinju Bioind Fdn, Ocean Pep, Jinju 52839, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191020
- 본문언어 영어
- Published As https://doi.org/10.3390/md19110614
- PubMed https://pubmed.ncbi.nlm.nih.gov/34822485
초록/요약
Models created by the intraperitoneal injection of lipopolysaccharide (LPS) and D-galactosamine (D-GalN) have been widely used to study the pathogenesis of human acute liver failure (ALF) and drug development. Our previous study reported that oyster (Crassostrea gigas) hydrolysate (OH) had a hepatoprotective effect in LPS/D-GalN-injected mice. This study was performed to identify the hepatoprotective effect of the tyrosine-alanine (YA) peptide, the main component of OH, in a LPS/D-GalN-injected ALF mice model. We analyzed the effect of YA on previously known mechanisms of hepatocellular injury in the model. LPS/D-GalN-injected mice showed inflammatory, apoptotic, ferroptotic, and pyroptotic liver injury. The pre-administration of YA (10 mg/kg or 50 mg/kg) significantly reduced the liver damage factors. The hepatoprotective effect of YA was higher in the 50 mg/kg YA pre-administered group than in the 10 mg/kg YA pre-administered group. These results showed that YA had a hepatoprotective effect by reducing inflammation, apoptosis, ferroptosis, and pyroptosis in the LPS/D-GalN-injected ALF mouse model. We suggest that YA can be used as a functional peptide for the prevention of acute liver injury.
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