An Interactive Online App for Predicting Diabetes via Machine Learning from Environment-Polluting Chemical Exposure Data
- 주제(키워드) Bayesian network , diabetes mellitus , environmental pollutants , glucose intolerance , machine learning
- 등재 SCIE, SSCI, SCOPUS
- OA유형 All Open Access, Gold, Green
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191084
- 본문언어 영어
- Published As https://doi.org/10.3390/ijerph19105800
- PubMed https://pubmed.ncbi.nlm.nih.gov/35627338
초록/요약
The early prediction and identification of risk factors for diabetes may prevent or delay diabetes progression. In this study, we developed an interactive online application that provides the predictive probabilities of prediabetes and diabetes in 4 years based on a Bayesian network (BN) classifier, which is an interpretable machine learning technique. The BN was trained using a dataset from the Ansung cohort of the Korean Genome and Epidemiological Study (KoGES) in 2008, with a follow-up in 2012. The dataset contained not only traditional risk factors (current diabetes status, sex, age, etc.) for future diabetes, but it also contained serum biomarkers, which quantified the individual level of exposure to environment-polluting chemicals (EPC). Based on accuracy and the area under the curve (AUC), a tree-augmented BN with 11 variables derived from feature selection was used as our prediction model. The online application that implemented our BN prediction system provided a tool that performs customized diabetes prediction and allows users to simulate the effects of controlling risk factors for the future development of diabetes. The prediction results of our method demonstrated that the EPC biomarkers had interactive effects on diabetes progression and that the use of the EPC biomarkers contributed to a substantial improvement in prediction performance. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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